Intravitreal triamcinolone acetonide inhibits choroidal neovascularization in a laser-treated rat model.

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Abstract
AGE-RELATED nacular degeneration (AMD), the leading cause of irreversible visual loss in the United States, has many treatment limitations. Steroid compounds are well-known antiangiogenic agents, which have been suggested as treatment for the choroidal neovascular membranes (CNVMs) that cause visual loss in exudative AMD.1-6 Although there are no direct animal models of AMD-related CNVMs, there are several animal models of CNVMs secondary to laser trauma. In the current study, we sought to characterize the effect of intravitreal triamcinolone acetonide(TAAC) on CNVM formation in a previously described and validated rat model of CNVM due to laser trauma.