Exocrinopathy resembling Sjögren's syndrome in HTLV-1 tax transgenic mice
- 1 September 1989
- journal article
- Published by Springer Nature in Nature
- Vol. 341 (6237) , 72-74
- https://doi.org/10.1038/341072a0
Abstract
Human T-cell leukaemia virus 1 (HTLV-1) is a retrovirus aetiologically associated with adult T-cell leukaemia (ATL), tropical spastic paraparesis (TSP) and possibly multiple sclerosis (MS) in humans. Three founder lines of transgenic mice containing the HTLV-1 tax gene under the control of the viral long terminal repeat (LTR) have previously been shown to develop neurofibromas. Further analysis of these animals has now revealed that they also develop an exocrinopathy involving the salivary and lachrymal glands. This pathology resembles Sjögren's syndrome, a disease of presumed autoimmune aetiology, features of which are sometimes reported in HTLV-1 associated conditions. Mice with an HTLV-1 tax transgene might be a useful model for studying the development of Sjögren-syndrome-like pathology.Keywords
This publication has 17 references indexed in Scilit:
- T-LYMPHOCYTE ALVEOLITIS, TROPICAL SPASTIC PARESIS, AND SJÖGREN SYNDROMEThe Lancet, 1988
- The tat Gene of Human T-Lymphotropic Virus Type 1 Induces Mesenchymal Tumors in Transgenic MiceScience, 1987
- A Transgenic Mouse Model for Human NeurofibromatosisScience, 1987
- HTLV-I AND HTLV-III ANTIBODIES AND TROPICAL SPASTIC PARAPARESISThe Lancet, 1985
- ANTIBODIES TO HUMAN T-LYMPHOTROPIC VIRUS TYPE-I IN PATIENTS WITH TROPICAL SPASTIC PARAPARESISPublished by Elsevier ,1985
- Isolation and characterization of retrovirus from cell lines of human adult T-cell leukemia and its implication in the disease.Proceedings of the National Academy of Sciences, 1982
- Natural Antibodies to Human Retrovirus HTLV in a Cluster of Japanese Patients with Adult T Cell LeukemiaScience, 1982
- Detection and isolation of type C retrovirus particles from fresh and cultured lymphocytes of a patient with cutaneous T-cell lymphomaProceedings of the National Academy of Sciences, 1980
- Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications.Proceedings of the National Academy of Sciences, 1979
- SJÖGRENʼS SYNDROMEMedicine, 1965