Programming the X Chromosome
- 30 January 2004
- journal article
- editorial
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 303 (5658) , 633-634
- https://doi.org/10.1126/science.1094408
Abstract
To compensate for the fact that females have two X chromosomes but males have only one, each female cell has one X chromosome inactivated. In females, it is the paternal X chromosome that is preferentially inactivated in all placental cells, but not in cells that develop into the embryo. In their Perspective, Hajkova and Surani discuss new work ( Okamoto et al ., Mak et al.) showing that the cells that develop into the embryo have an inactivated paternal X at the start of embryogenesis, which becomes reactivated during the early stages of development.Keywords
This publication has 12 references indexed in Scilit:
- Reactivation of the Paternal X Chromosome in Early Mouse EmbryosScience, 2004
- Epigenetic Dynamics of Imprinted X Inactivation During Early Mouse DevelopmentScience, 2004
- Inheritance of a pre-inactivated paternal X chromosome in early mouse embryosNature, 2003
- Consequences of the depletion of zygotic and embryonic enhancer of zeste 2 during preimplantation mouse developmentDevelopment, 2003
- The Homeoprotein Nanog Is Required for Maintenance of Pluripotency in Mouse Epiblast and ES CellsCell, 2003
- Functional Expression Cloning of Nanog, a Pluripotency Sustaining Factor in Embryonic Stem CellsCell, 2003
- Role of Histone H3 Lysine 27 Methylation in X InactivationScience, 2003
- Establishment of Histone H3 Methylation on the Inactive X Chromosome Requires Transient Recruitment of Eed-Enx1 Polycomb Group ComplexesDevelopmental Cell, 2003
- Nuclear reprogramming of somatic cells by in vitro hybridization with ES cellsCurrent Biology, 2001
- The foundation of two distinct cell lineages within the mouse morulaCell, 1981