Pathways of Carbohydrate Metabolism in Normal and Neoplastic Cells

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Abstract
Uronic Acid PathwayAn additional cyclic pathway for the metabolism of hexose phosphate has recently come to light. This pathway (Fig. 10) appears to function in the synthesis of ascorbic acid, with uronic acids as precursors. In man the operation of this pathway becomes evident only when it is blocked, as in congenital pentosuria.Glucuronic acid has been shown to serve as precursor for both ascorbic acid46 and L͇-xylulose,47 and recently some of the steps in this conversion have been elucidated.48 49 50 The reduction of glucuronic acid to L͇-gulonic acid is catalyzed by a dehydrogenase present in both plant and animal . . .