In Vivo and In Vitro Studies on the Morphogenesis of Tumors Induced by Murine Sarcoma Virus (Harvey) 2

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Abstract
Murine sarcoma virus (Harvey) (MSV-H) rapidly induces angiosarcomas in newborn mice. Explants from these tumors cultured on collagen-coated surfaces gave rise to cell lines of different mesenchymal types. These included myogenic cells which produced rhabdomyosarcomas in vivo. However, when the myogenic cells grown from a si.ngle cell were cultured on plastic surfaces and then implanted in mice, fibrosarcomatous tumors were obtained. Other cell lines grown on a collagen-coated substrate induced fibrosarcomas, undifferentiated sarcomas, and angiosarcomas more consistent with the histology of the virus-induced tumor. Only one of the established cell lines, which produced a fibrosarcoma on transplantation, grew readily on a conventional plastic surface. The relationship of the cells obtained in vitro to the morphogenesis of the tumor is discussed.

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