Cryptorchidism and Testicular Cancer

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Abstract
An analysis of 125 patients with a history or clinical evidence of cryptorchidism and testicular germinal tumor treated from 1934 to 1975 is presented. Cryptorchidism was corrected ipsilaterally or contralaterally in 83 patients with intrascrotal testis cancer when they were 4-42 yr old, spontaneously (21 patients), by orchiopexy (51 patients) or by hormonal therapy (11 patients). Forty-two cryptorchid patients (uncorrected cases) presented with ipsilateral inguinal (24 patients), abdominal (14 patients) or contralateral intrascrotal tumors (4 patients). Tumor histologic types on orchiectomy were pure seminoma in 54 patients, embryonal carcinoma in 35, teratocarcinoma in 33 and pure choriocarcinoma in 3. The 5 yr survival rates were 60% for the corrected cases and 63% for the uncorrected cases according to cryptorchid state; they were 78% in patients with pure seminoma and 48% in patients with other germinomas according to histologic type. The majority (58 of 73) of 5 yr survivors received regional lymphatic irradiation, in 39 patients with pure seminoma, and/or systemic chemotherapy in 19 patients with germinal carcinomas, with or without regional lymphadenectomy.