Mitomycin C and Temperature Induction of Colicin B in the Absence of Deoxyribonucleic Acid Synthesis
- 1 September 1971
- journal article
- Published by American Society for Microbiology in Journal of Bacteriology
- Vol. 107 (3) , 633-5
- https://doi.org/10.1128/jb.107.3.633-635.1971
Abstract
An Escherichia coli K-12 strain and its mutant, temperature-sensitive in deoxyribonucleic acid (DNA) synthesis, were used as hosts for two different ColB factors (ColB3-K166 and ColB4-K98). Induction of either colicin occurred in both hosts in the presence of mitomycin C at 42 C. Induction of the temperature-sensitive colicinogenic hosts also occurred without mitomycin C at 42 C at which temperature no DNA synthesis was observed. Colicin synthesis was a nonlethal event in ColB4-K98 + cultures, whereas in cultures of ColB3-K166 + induction led to death of a large fraction of the population.Keywords
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