Toxicity Studies of General Chemical 4072 and Two Related Compounds to Cattle

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Abstract
General Chemical 4072 (2-chloro-l-(2,4-dichlorophenyl)vinyl diethyl phosphate) has shown usefulness in entomological practice, as have 2 related materials, General Chemicals compounds 3582(l-(2,5-dichlorophenyl)-2-2-dichlorovinyl diethyl phosphate) and 3583(2-chloro-l-(2,4-dichlorophenyl) vinyl diethyl phosphate). The 3 compounds are inhibitors of mammalian cholinesterase. Preliminary toxicological evaluations indicate that compound 4072 should not be used on cattle at a concentration greater than 0.25% and that this concentration could probably also be used on young calves. For oral administration 10 mg/kg would appear to be the maximum permissible. In the same manner a concentration of 0.1% to 0.25% of compound 3582 would appear to be the maximum safe dosage. Compound 3583 appears to be toxic at the dosages required for control of animal parasites. All three compounds induce salivation, dyspnea, muscular weakness, and diarrhea in animals given excessive dosages. These effects are effectively reversed by the administration of adequate amounts of atropine sulfate. Recovery from poisoning is usually rapid and complete.

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