Effects of neonatal medroxyprogesterone acetate on postnatal sexual differentiation of female rats

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Abstract
Medroxyprogesterone acetate (MPA), 5 .mu.g/g body wt, was given to lactating female rats 1 day after parturition. Group 1 females suckled 10-12 young, with equal numbers of males and females, while group 2 females each suckled 10 female young. The young were weaned at 21 days of age. Exposure to MPA advanced the day of vaginal opening by 1 day, and increased anogenital distance in group 2 young. At autopsy between 80 and 100 days of age, the clitoris of group 2 females was significantly greater than in controls, and ovarian and adrenal weights were reduced. [Clinical implications are discussed.].