A Controlled Study of Preoperative Irradiation in Cancer of the Sigmoid Colon and Rectum

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Abstract
The authors initiated a prospective controlled study to determine the clinical effect of low-dose preoperative irradiation on clinically operable patients with histologically proved adenocarcinoma of the colon or rectum. Preoperative irradiation had no demonstrable effect upon the incidence of surgical complications or upon mortality during the first three months after resection. The pathologist identified lymph nodes in 24% of the resected x-ray cases and in 38% of the controls. Lymphatic invasion and serosal penetration were also reported significantly less frequently for the irradiated. No remarkable differences were seen when survival from operation was computed for subgroups of resected cases.

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