Vitamin B 12 and the Megaloblastic Development
- 5 October 1973
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 182 (4107) , 78-79
- https://doi.org/10.1126/science.182.4107.78
Abstract
In patients with vitamin B12 deficiency, phytohemagglutinin-stimulated cultured lymphocytes had little or no thymidylate synthetase activity. Ample activity was found in such lymphocytes from normal individuals and patients with folic acid deficiency or pernicious anemia in remission. It therefore appears that the megaloblastosis that is associated with vitamin B12 deficiency is related to low thymidylate synthetase activity.Keywords
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