Clinical Notes on the Possible Anticholinergic Reversal of Depressive Syndromes

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Abstract
The effects were studied of acute confusional states and deliria (pharmacogenic confusional syndromes-PCS), occurring under the influence of psychotropic drugs [thioridazine, imipramine, promethazine, l-mepromazine, amitriptyline], on the depressive syndrome of 3 patients. The favorable influence of PCS on the depressive syndrome is considered to be largely linked to the anticholinergic effect of the drugs. The observations made in these 3 patients may give support to the hypothesis that cholinergic activity has pathogenic significance in depressive syndromes.

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