The Coagulation Mechanism: With Specific Reference to the Interpretation of Prothrombin Time Values and a Consideration of the Prothrombin Consumption Time

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Abstract
The major defects in coagulation can be divided into 2 large classes: namely those in which prothrombin activity is reduced (hypoprothrombinemia), and those in which there is a lack of available thromboplastin. In the 1st class can be grouped deficiencies of the various components of the prothrombin complex including the classical prothrombin itself, the labile factor, and perhaps other agents. In the latter group are: diminished thromboplastinogen (the basic defect in hemophilia), insufficient platelet enzyme (thrombocyto-penic purpura), and platelet enzyme inhibitor (hemophilia-like disease). The one-stage prothrombin method determines quantitatively prothrombin activity while the prothombin consumption test estimates available thromboplastin. By means of these 2 tests the type of the hemorrhagic defect can be made. The details of the prothrombin consumption test are described.
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