Cytotoxic Effects of Recombinant Human Biological Response Modifiers on Head and Neck Carcinoma Cells
- 1 January 1988
- journal article
- research article
- Published by S. Karger AG in ORL
- Vol. 50 (3) , 150-155
- https://doi.org/10.1159/000275983
Abstract
The present report shows that the simultaneous application of two biological response modifiers (recombinant human γ-interferon plus recombinant human α-tumor necrosis factor) has a lethal effect on living laryngeal and salivary gland carcinomas. A cytostatic or cytotoxic effect of the two substances alone could only be observed in occasional cases. The results suggest a synergistic action of γ-interferon and α-tumor necrosis factor that might be of therapeutic value for head and neck carcinomas in the future.Keywords
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