Inhibitory effect of human chorionic gonadotropin (hCG) on HIV‐1 transmission from lymphocytes to trophoblasts
- 31 August 1992
- journal article
- Published by Wiley in FEBS Letters
- Vol. 309 (1) , 82-84
- https://doi.org/10.1016/0014-5793(92)80744-2
Abstract
It has been demonstrated that human chorionic gonadotropin (hCG) inhibits HIV production in vitro, suggesting that this soluble placental glycoprotein can control viral replication and spread in vivo, hCG - the major product of fetal trophoblasts - was tested on an in vitro model consisting of choriocarcinoma-derived ENAMI trophoblasts exposed to HIV-infected MOLT-4 lymphocytes. The results show a U-shaped antiviral dose- effect and suggest that hCG may contribute to protection against intrauterine transmission of HIV-1.Keywords
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