The Tissue Catechol Amine Concentration of the Human Heart Determined by the Aluminum Hydroxide-Arsenomolybdic Acid Method

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Abstract
With the aluminum hydroxide-arsenomolybdic acid method, which has recently been extensively modified in this laboratory, the tissue concentration of catechol amines was determined in 100 human hearts. The results were correlated with clinical history and autopsy findings. Previous work has suggested that cardiovascular disease and uremia were associated with an elevation in the heart catechol amine concentration, and that some cases of sudden death were associated with an elevated heart catechol amine concentration. In this study cardiovascular disease and uremia showed low or low normal values while not a single instance of sudden death could be explained by an abnormally elevated heart catechol amine concentration.