CA 125: The End of the Beginning
- 1 January 2001
- journal article
- editorial
- Published by Springer Nature in Tumor Biology
- Vol. 22 (6) , 345-347
- https://doi.org/10.1159/000050637
Abstract
CA 125, a high-molecular-weight mucin, was first defined in 1981 by the monoclonal antibody OC125. Until recently, it has defied many attempts to purify it from a variety of sources, although many research groups have successfully raised antibodies that bind to CA 125. Nevertheless, CA 125 has demonstrated its considerable value as a marker in monitoring patients with ovarian cancer. This year, two research groups have succeeded in cloning the high-molecular-weight mucin CA 125. Their findings are summarized and the significance discussed in light of existing data from the human genome.Keywords
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