Comparison of the Effects of Continuous and Intermittent Systemic Administration on the Penetration of Gentamicin into Infected Rabbit Eyes

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Abstract
The effect of the mode of administration on the intraocular penetration of gentamicin in rabbits with bacterial endophthalmitis was examined. Animals were treated over a period of 12 hr either by intramuscular injection every 3 hr or by continuous intravenous infusion; both groups received the same total dose of drug. The mean peak and trough levels in serum with intramuscular injection were 11.4 and 1.6 µg/ml, respectively. Mean serum levels during continuous infusion were ∼7 µg/ml. The area under the time-concentration curve for serum was approximately the same in both groups. Mean vitreous humor levels at the end of therapy were 2.8 µg/ml in the animals treated by repeated intramuscular injection and 2.6 µg/ml in those treated by continuous infusion (P > 0.2). In this model, the intraocular penetration of gentamicin was not influenced by the mode of systemic administration.