The use of acetylethyleneimine in the production of inactivated foot-and-mouth disease vaccines
- 1 September 1963
- journal article
- research article
- Published by Cambridge University Press (CUP) in Epidemiology and Infection
- Vol. 61 (3) , 337-344
- https://doi.org/10.1017/s0022172400039620
Abstract
Suspensions of FMD virus treated with 0·05% formalin at 26° C. for periods up to 144 hr. remained infective for cattle, although the infectivity could not be detected in the presence of aluminium hydroxide. Infectivity was detected in similar virus suspensions which had been treated with 0·05% AEI at 37° C. for 8 hr. but not in suspensions treated for 12 hr.Vaccines prepared from these suspensions were antigenically potent and serum neutralization tests demonstrated the development and regression of serum antibody. The AEI vaccines were at least as potent as the corresponding formalin vaccines.Keywords
This publication has 7 references indexed in Scilit:
- The Tissue Culture Colour Test for Assaying the Virus and Neutralizing Antibody of Foot-and-Mouth Disease and its Application to the Measurement of Immunity in CattleResearch in Veterinary Science, 1961
- Application of Agar-Gel Diffusion Analysis to a Study of the Antigenic Structure of Inactivated Vaccines Prepared from the Virus of Foot-and-Mouth DiseaseThe Journal of Immunology, 1959
- The inactivation of foot-and-mouth disease virus by formalinArchiv für die gesamte Virusforschung, 1957
- Growth and Titration of the Viruses of Foot-and-Mouth Disease and Vesicular Stomatitis in Kidney Monolayer Tissue CulturesNature, 1955
- Significance of tests for non-infectivity of foot-and-mouth disease vaccinesEpidemiology and Infection, 1952
- Propagation of strains of foot-and-mouth disease virus in unweaned white mice.1951
- Research on foot-and-mouth disease. III. The cultivation of the virus on a practical scale in explantations of bovine tongue epithelium.1951