Lipotoxicity and glucotoxicity in type 2 diabetes
- 1 April 2001
- journal article
- research article
- Published by Taylor & Francis in Postgraduate Medicine
- Vol. 109 (4) , 55-64
- https://doi.org/10.3810/pgm.2001.04.908
Abstract
Lipotoxicity and glucotoxicity may both be implicated in the pathogenesis of type 2 diabetes. Excess circulating fat, glucose, or both act on diverse cells and tissues to counteract insulin-mediated glucose uptake, hepatic regulation of glucose output, and insulin secretion. In this article, Dr Sivitz reviews the biochemistry and clinical implications of these conditions and how to manage them through lifestyle modifications.This publication has 23 references indexed in Scilit:
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