Studies on histones. 6. Observations on the biosynthesis of histones and other proteins in regenerating rat liver
- 1 May 1963
- journal article
- research article
- Published by Portland Press Ltd. in Biochemical Journal
- Vol. 87 (2) , 330-334
- https://doi.org/10.1042/bj0870330
Abstract
The incorporation in vivo of L-[14C]lysine into nuclear and microsomal protein fractions in regenerating liver was studied at various intervals after partial hepatectomy. Incorporation into histone was depressed 1.5-12 hr. and equal and above average 12-22.5 hr. after the operation; incorporation into the hydrochloric acid-insoluble fractions of nuclei and of the perfluoro-octanoate pellet was relatively enhanced to varying extents during the whole period. The results make it probable that the synthesis of histone required for cell division begins before the synthesis of DNA.Keywords
This publication has 15 references indexed in Scilit:
- Studies on histones. 5. The histones of the Crocker sarcoma and spontaneous mammary tumours of miceBiochemical Journal, 1963
- The presence of basic proteins in microsomesBiochimica et Biophysica Acta, 1960
- Improved fractionations of arginine-rich histones from calf thymusBiochemical Journal, 1960
- Relative Metabolic Activities of Histones in Tumours and LiverBritish Journal of Cancer, 1960
- Fractionation of proteins of the microsomes of rat liver by means of a non-ionic detergentBiochemical Journal, 1958
- LABELING OF HISTONES AND OTHER NUCLEAR PROTEINS WITH L-LYSINE-U-C14 IN TISSUES OF TUMOR-BEARING RATS1958
- A MICROPHOTOMETRIC STUDY OF THE SYNTHESES OF DESOXYRIBONUCLEIC ACID AND NUCLEAR HISTONEThe Journal of cell biology, 1955
- The incorporation in vivo of labeled amino acids into subfractions of liver cytoplasm fractions.1955
- The incorporation of 15N, 35S and 14C into nucleic acids and proteins of rat liverBiochimica et Biophysica Acta, 1953
- AMINO ACID “INCORPORATION” IN VITRO BY DESOXYPENTOSE NUCLEOPROTEIN AND HISTONEJournal of Biological Chemistry, 1952