INFLUENCE OF THE ADRENAL CORTEX ON GROWTH PROCESSES IN THE RAT MAMMARY GLAND

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Abstract
SUMMARY The role of adrenal cortical hormones in the response of the rat mammary gland to testosterone was studied in Sprague-Dawley rats. In gonadectomized rats with intact adrenals, local percutaneous application of testosterone stimulated lobulo-alveolar development in the mammary glands. This effect of testosterone was markedly reduced after adrenalectomy. Injections of cortisone into the adrenalectomized rats restored the mammary gland response to testosterone, whereas injections of oestrone did not. In adrenalectomized and hypophysectomized rats, injections of testosterone in combination with growth hormone produced a marked alveolar development in the mammary glands. The importance of gonadal, hypophysial and adrenocortical hormones for various growth processes in the mammary glands is discussed.

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