Redox Regulation of NF-κB Activation: Distinct Redox Regulation Between the Cytoplasm and the Nucleus
Top Cited Papers
- 1 March 2005
- journal article
- review article
- Published by Mary Ann Liebert Inc in Antioxidants and Redox Signaling
- Vol. 7 (3-4) , 395-403
- https://doi.org/10.1089/ars.2005.7.395
Abstract
Reduction/oxidation (redox) regulation mediates numerous cellular responses and contributes to several physiological diseases. The transcription factor nuclear factor κB (NF-κB) is known to be a redox-sensitive factor. NF-κB plays a central role in immune responses and inflammation, through regulation of the gene expression of a large number of cytokines and other immune response genes. NF-κB is trapped in the cytoplasm in stimulated cells and translocates into the nucleus in response to several stimuli, including oxidative stress. Reactive oxygen species enhance the signal transduction pathways for NF-κB activation in the cytoplasm and translocation into the nucleus. In contrast, the DNA binding activity of oxidized NF-κB is significantly diminished, and that activity is restored by reducing enzymes, such as thioredoxin or redox factor 1. This review describes the signal transduction pathways for NF-κB activation and redox regulation of NF-kB activation in the cytoplasm and nucleus. Antioxid. Redox Signal. 7, 395–403.Keywords
This publication has 96 references indexed in Scilit:
- Protein Kinase Cδ Selectively Regulates Protein Kinase D-Dependent Activation of NF-κB in Oxidative Stress SignalingMolecular and Cellular Biology, 2004
- Hydrogen peroxide activates IκB kinases through phosphorylation of serine residues in the activation loopsFEBS Letters, 2002
- Targeting of the c-Abl Tyrosine Kinase to Mitochondria in the Necrotic Cell Death Response to Oxidative StressJournal of Biological Chemistry, 2001
- Nucleoredoxin, Glutaredoxin, and Thioredoxin Differentially Regulate NF-κB, AP-1, and CREB Activation in HEK293 CellsBiochemical and Biophysical Research Communications, 2000
- Recent advances torwards understanding redox mechanisms in the activation of nuclear factor κbFree Radical Biology & Medicine, 2000
- N‐Acetylcysteine suppresses TNF‐induced NF‐κB activation through inhibition of IκB kinasesFEBS Letters, 2000
- Aberrant rel/nfkb genes and activity in human cancerOncogene, 1999
- Structure of an IκBα/NF-κB ComplexPublished by Elsevier ,1998
- The Crystal Structure of the IκBα/NF-κB Complex Reveals Mechanisms of NF-κB InactivationCell, 1998
- The Transcriptional Activity of NF-κB Is Regulated by the IκB-Associated PKAc Subunit through a Cyclic AMP–Independent MechanismCell, 1997