Diffusion tensor in posterior cingulate gyrus: correlation with cognitive decline in Alzheimer??s disease
- 1 December 2002
- journal article
- Published by Wolters Kluwer Health in NeuroReport
- Vol. 13 (17) , 2299-2302
- https://doi.org/10.1097/00001756-200212030-00026
Abstract
To determine whether the diffusion abnormalities in brains with Alzheimer's disease (AD) correlate with disease severity, we studied 34 AD patients using diffusion tensor MRI. Mean diffusivity and fractional anisotropy (FA) as well as three eigenvalues (lambda1, lambda2, and lambda3) of the diffusion tensor of the posterior cingulate white matter correlated with the Mini-Mental State Examination (MMSE) score. The mean diffusivity and the three eigenvalues showed significant correlation with the MMSE score. On the other hand, no significant correlation was seen between the FA and MMSE score. Our results suggested that mean diffusivity and the eigen-values, but not FA, reflect progression of AD-related histopathlogical changes in the posterior cingulate white matter and may be useful biological indices to monitor AD.Keywords
This publication has 20 references indexed in Scilit:
- Imaging of onset and progression of Alzheimer's disease with voxel-compression mapping of serial magnetic resonance imagesThe Lancet, 2001
- Rates of hippocampal atrophy correlate with change in clinical status in aging and ADNeurology, 2000
- Immunization with amyloid-β attenuates Alzheimer-disease-like pathology in the PDAPP mouseNature, 1999
- Diffusion-Weighted Magnetic Resonance Imaging in Alzheimer’s DiseaseDementia and Geriatric Cognitive Disorders, 1999
- A 24-week, double-blind, placebo-controlled trial of donepezil in patients with Alzheimer's diseaseNeurology, 1998
- Increased Water Diffusion in Cerebral White Matter in Alzheimer’s DiseaseGerontology, 1997
- Microstructural and Physiological Features of Tissues Elucidated by Quantitative-Diffusion-Tensor MRIJournal of Magnetic Resonance, Series B, 1996
- A 30-Week Randomized Controlled Trial of High-Dose Tacrine in Patients With Alzheimer's DiseaseJAMA, 1994
- MR imaging of intravoxel incoherent motions: application to diffusion and perfusion in neurologic disorders.Radiology, 1986
- Spin Diffusion Measurements: Spin Echoes in the Presence of a Time-Dependent Field GradientThe Journal of Chemical Physics, 1965