Structure-activity relationship of quinazolinedione inhibitors of calcium-independent phosphodiesterase
- 1 February 1991
- journal article
- Published by American Chemical Society (ACS) in Journal of Medicinal Chemistry
- Vol. 34 (2) , 624-628
- https://doi.org/10.1021/jm00106a024
Abstract
A series of quinazolinediones and azaquinazolinediones is described which possess potent inhibitory activity toward the calcium-independent phosphodiesterase enzyme (CaIPDE). In vivo testing showed that this in vitro activity translates to animal models predictive of chronic diseases such as depression and inflammation. These results support the hypothesis that inhibition of CaIPDE may lead to useful activity in such chronic diseases.Keywords
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