Effect of PCO2 on the relation of lactate and excess lactate to O2 deficit

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Abstract
Because changes in PCO2 [arterial blood CO2 tension] alone affect blood levels of lactate, these experiments were designed to ascertain the effect of arterial PCO2 level on the relationships of increases in blood lactate (AL) and excess lactate (XL) to the O2 deficit incurred during hypoxia. Twelve anesthetized dogs were made hypoxic for 30 min. while eucapnic (PCO2 = 40 torr), and again while hypercapnic (PCO2 = 77 torr) with appropriate control and recovery periods. Another group of 12 were treated similarly except they were hypocapnic (PCOo = 18 torr) during 1 hypoxic period, and eucapnic during the other. The net O2 deficit (NOD) was estimated from the decrease in VO2 [O2 ventilation] from the base-line value just prior to hypoxia and corrected for changes in O2 stores. A linear relationship was obtained for AL and NOD which was different at each level of PCO2, and which varied inversely with PCO2 level. Similar results were obtained for the relationship of XL to NOD. On this basis, the more complicated measure of excess lactate offered no advantage over the simpler measurement of the lactate increase.

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