Perfect Simulation From Nonneutral Population Genetic Models: Variable Population Size and Population Subdivision

1 November 2006

journal article
Published by Oxford University Press (OUP) in Genetics

Vol. 174 (3) , 1397-1406
https://doi.org/10.1534/genetics.106.060681

Abstract

We show how the idea of monotone coupling from the past can produce simple algorithms for simulating samples at a nonneutral locus under a range of demographic models. We specifically consider a biallelic locus and either a general variable population size mode or a general migration model for population subdivision. We investigate the effect of demography on the efficacy of selection and the effect of selection on genetic divergence between populations.

Keywords

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