Increasing 5-lipoxygenase inhibitory activities by oxidative conversion of o-methoxyphenols to catechols using a Cu2+-ascorbic acid-O2 system.
- 1 January 1990
- journal article
- letter
- Published by Pharmaceutical Society of Japan in CHEMICAL & PHARMACEUTICAL BULLETIN
- Vol. 38 (3) , 842-844
- https://doi.org/10.1248/cpb.38.842
Abstract
Several complicated o-methoxyphenols were oxidized with high selectivity to catechols by a Cu2+- ascorbic acid -O2 system. In this way, the RBL-1 5-lipoxygenase inhibitory activities of o-methoyphenols were greatly increased. [6]-Norgingerol (4), a novel compound derived from [6]-gingerol (3), shows promise as a lead compound for new drugs because of its high inhibitory potency (IC50 .times. 10-8 M).This publication has 1 reference indexed in Scilit:
- Disulfide cleavage and insulin denaturation by active oxygen in the copper(II)/ascorbic acid system.CHEMICAL & PHARMACEUTICAL BULLETIN, 1985