Direct Evidence That Endogenous G M1 Ganglioside Can Mediate Thymocyte Proliferation
- 13 December 1985
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 230 (4731) , 1285-1287
- https://doi.org/10.1126/science.2999979
Abstract
The B subunit of cholera toxin, which is multivalent and binds exclusively to a specific ganglioside, GM1, was mitogenic for rat thymocytes. When exposed to the B subunit, the cells proliferated, as measured by 3H-labeled thymidine incorporation. Mitogenesis depended on the direct interaction of the B subunit with GM1 on the surface of the cells. This demonstrates that endogenous plasma membrane gangliosides can mediate proliferation in lymphocytes.This publication has 35 references indexed in Scilit:
- A common sequence of calcium and pH signals in the mitogenic stimulation of eukaryotic cellsNature, 1985
- Voltage-gated K+ channels in human T lymphocytes: a role in mitogenesis?Nature, 1984
- Lectin- and ionophore-stimulated Ca2+ influx in murine lymphocytes: Inhibition by disialogangliosideCellular Immunology, 1983
- Soluble Gangliosides in Cultured Neurotumor CellsJournal of Neurochemistry, 1983
- Translocation of newly synthesized gangliosides to the cell surfaceBiochemistry, 1982
- Role of membrane gangliosides in the binding and action of bacterial toxinsThe Journal of Membrane Biology, 1982
- GM3 ganglioside induces hamster fibrobiast growth inhibition in chemically-defined medium: Ganglioside may regulate growth factor receptor functionBiochemical and Biophysical Research Communications, 1982
- Cholera toxin stimulates division of 3T3 cellsJournal of Cellular Physiology, 1979
- Growth factors and gangliosides: A possible new perspective in neuronal growth controlJournal of Supramolecular Structure, 1979
- INTERACTION OF CHOLERA TOXIN AND TOXIN DERIVATIVES WITH LYMPHOCYTESThe Journal of Experimental Medicine, 1974