CYCLOPHOSPHAMIDE IN TREATMENT OF IDIOPATHIC NEPHROTIC SYNDROME

  • 1 January 1976
    • journal article
    • research article
    • Vol. 57  (6) , 948-951
Abstract
Patients (53) 3 1/2-20 yr of age with steroid-dependent idiopathic nephrotic syndrome (INS) were treated with cyclophosphamide and prednisone. Two dosage schedules were used: a short course (SC) at 3-5 mg/kg per day for 6-8 wk and a longer course (LC) at 3-5 mg/kg per day for 8 wk followed by 1.5-2.5 mg/kg for an additional 4 wk. Prednisone was administered concurrently at 50-75 mg/m2 every other day. Patients (29) were in the SC group and 24 in the LC group. The 2 groups did not differ significantly as to age at onset of idiopathic nephrosis nor as to the duration of the INS prior to cyclophosphamide therapy. All patients were followed for a minimum of 42 mo. after cyclophosphamide therapy. The SC was associated with a higher relapse rate during the 1st yr than the LC (42% and 8%, respectively, .01 < P > .025). At 42 mo. 63% of the LC group were in remission compared with 21% in the SC group.

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