EPINEPHRINE, PREGNENOLONE AND TESTOSTERONE IN THE TREATMENT OF RHEUMATOID ARTHRITIS

27 May 1950

journal article
research article
Published by American Medical Association (AMA) in JAMA

Vol. 143 (4) , 338-344
https://doi.org/10.1001/jama.1950.02910390010003

Abstract

Reports of the effectiveness of cortisone (Kendall's compound E, or 17-hydroxy-11-dehydrocorticosterone) and of pituitary adrenocorticotropic hormone (ACTH) in the treatment of rheumatoid arthritis and spondylitis¹have given rise to the hope that substances known to stimulate endogenous production or liberation of pituitary adrenocorticotropic hormone might also be effective in these conditions. Vogt²demonstrated in several different species of animals that the amount of active cortical material released into the suprarenal vein in one minute is many times that which can be extracted from both adrenal cortices by present methods. The administration, of epinephrine was found to increase the amount of cortical material which could be recovered from suprarenal venous blood by several hundred per cent.³Her results suggested that epinephrine, administered in doses approaching the amounts that might be liberated normally within the body, stimulates the adrenal cortex directly. Long⁴concluded that the action of epinephrine

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