Darlucins A and B, New Isocyanide Antibiotics from Sphaerellopsis filum(Darluca filum).

1 January 1995

journal article
Published by Japan Antibiotics Research Association in The Journal of Antibiotics

Vol. 48 (1) , 36-41
https://doi.org/10.7164/antibiotics.48.36

Abstract

Two new xanthocillin type antibiotics, darlucin A (1) and B (2), were isolated from fermentations of Sphaerellopsis filum (Darluca filum). Their structures were established by spectroscopic methods. The darlucins are the first known compounds with a 1,2-diisocyanoalkene moiety. Both compounds exhibited antibacterial, antifungal and weak cytotoxic activities.

Keywords

STRUCTURES
DARLUCINS
ISOCYANIDE
ANTIBIOTICS
SPHAERELLOPSIS
ANTIFUNGAL
ANTIBACTERIAL
DIISOCYANOALKENE
WEAK
CYTOTOXIC

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