One-pot Three-step Solution Phase Syntheses of Thiohydantoins using Microwave Heating
- 4 December 2001
- journal article
- letter
- Published by Georg Thieme Verlag KG in Synlett
- Vol. 2001 (12) , 1893-1896
- https://doi.org/10.1055/s-2001-18739
Abstract
An efficient one-pot three-step solution phase protocol suitable for library syntheses of thiohydantoins was developed. The reactions included are in the following order, Negishi or Suzuki C-C coupling reactions, reductive amination and finally a cyclisation reaction. Protocols using a solid supported reagent and protocols suitable for combinatorial chemistry were developed, all including microwave heating.Keywords
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