MECHANISMS OF RECOVERY FROM HERPESVIRUS INFECTIONS - REVIEW

  • 1 January 1978
    • journal article
    • review article
    • Vol. 42  (4) , 414-427
Abstract
A variety of specific immunological mechanisms were effective at neutralizing herpesvirus or destroying herpesvirus infected human cells. Humoral and cell-mediated immune responses or combinations thereof are included. Humoral immunity is probably responsible for preventing reinfection. Cellular immunity, mediated by T [thymus-derived] lymphocytes or by the interaction of antibody and Fc [immunoglobulin constant region] receptor bearing cells, is more important in recovery from infections. A number of additional nonspecific cellular and humoral components inhibited the progression of virus replication and were implicated in assisting the host in the recovery process. Various interactions and counteractions between nonspecific and specific components of the immune response are discussed with respect to their role in recovery from primary and recurrent disease and how they may be manipulated to control herpesvirus recrudescent disease.