Crystal structure of an HIV-binding recombinant fragment of human CD4
- 29 November 1990
- journal article
- research article
- Published by Springer Nature in Nature
- Vol. 348 (6300) , 419-426
- https://doi.org/10.1038/348419a0
Abstract
CD4 glycoprotein on the surface of T cells helps in the immune response and is the receptor for HIV infection. The structure of a soluble fragment of CD4 determined at 2.3 Å resolution reveals that the molecule has two intimately associated immunoglobulin-like domains. Residues implicated in HIV recognition by analysis of mutants and antibody binding are salient features in domain Dl. Domain D2 is distinguished by a variation on the β-strand topologies of antibody domains and by an intra-sheet disulphide bridge.Keywords
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