LIVER-CELL SURFACE EXPRESSION OF THE ANTIGEN REACTING WITH LIVER-KIDNEY MICROSOMAL ANTIBODY (LKM)

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  • 1 January 1984
    • journal article
    • research article
    • Vol. 55  (1) , 36-40
Abstract
To test the hypothesis that liver membrane antibodies, found in all liver-kidney microsomal antibody (LKM) positive sera from patients with chronic active hepatitis, were directed against antigens shared by both hepatocellular endoplasmic reticulum and plasma membranes, absorption experiments were performed using viable isolated hepatocytes and liver microsomes as antigens. Results are in agreement with the above hypothesis. LKM, which displays a restricted organ specificity, is able to react with antigenic determinants expressed on the liver cell surface, as it has been demonstrated for strictly organ specific antibodies directed against thyroid, adrenal and gastric parietal cell microsomes.