REDUCTION OF INDOMETHACIN-INDUCED GASTROINTESTINAL BLOOD-LOSS BY SODIUM SALICYLATE IN MAN

  • 1 January 1978
    • journal article
    • research article
    • Vol. 16  (12) , 610-611
Abstract
The gastrointestinal bleeding during treatment with indomethacin, aspirin, phenylbutazone and sodium salicylate in healthy human subjects was determined. Gastrointestinal blood loss was determined by a modified 57Cr-labelled erythrocyte method. Collected stool was incinerated and radioactivity of ashes was determined. Rheumatic patients were treated for 4 wk with indomethacin alone or with indomethacin combined with sodium salicylate. The gastrointestinal blood loss was determined on the last 4 days of treatment. Blood loss was significantly reduced by combined treatment in comparison to monotherapy with indomethacin, while combined treatment had a marked antirheumatic effect.

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