Increased Potassium Permeability Induced In Vitro by Menadione in Normal Human Red Cells

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Abstract
Normal red blood cells, preincubated for 75 min with 1.15 mM menadione sodium bisulfite lose potassium and water on subsequent incubation at 37° C for 24 h without menadione.The potassium loss is increased by addition of calcium and prevented by addition of glucose.Since normal red cells treated with menadione behave like untreated hypochromic cells, both from β‐thalassaemia or iron deficiency anaemia in respect to membrane permeability to potassium, it may be supposed that menadione induces in normal red cells an abnormality similar to that naturally occurring in hypochromic cells.