Comparison of the in vitro antifungal activity of free and liposome-encapsulated amphotericin B

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Abstract
One hundred and four pathogenic yeast isolates (32Candida albicans, 20 Candida tropicalis, 20Candida parapsilosis and 32Cryptococcus neoformans) and 21 mould isolates (13Aspergillus spp. and eightFusarium spp.), most of which were isolated from patients with cancer, were tested for susceptibility to free amphotericin B and a small unilamellar liposomal formulation of amphotericin B using a microbroth dilution method. Minimal fungicidal concentrations were also determined forCandida spp. andCryptococcus neoformans. The minimal inhibitory concentrations of liposomal amphotericin B were comparable with those of the free drug; furthermore, the fungicidal activity of these two drugs did not differ significantly.