Humoral responses against the C-terminal region of merozoite surface protein 1 can be remembered for more than 30 years in persons exposed to Plasmodium vivax
- 1 March 2004
- journal article
- Published by Springer Nature in Zeitschrift Fur Parasitenkunde-Parasitology Research
- Vol. 92 (5) , 384-389
- https://doi.org/10.1007/s00436-003-1009-0
Abstract
Most people infected with Plasmodium vivax malaria developed antibodies against the C-terminal region of P. vivax merozoite surface protein (PvMSP1c) and the antibodies are sustained for a period up to 10 months after anti-malarial treatment. The longer-term stability of the specific humoral response was evaluated indirectly by determining the antibody titers in the sera from healthy individuals who lived an area from which malaria had been eradicated (450 persons) and an area in which it had recurred (1,524 persons). There were considerable residual antibody responses to PvMSP1c in over 15% of sera from healthy individuals, but only those who had lived in the era when malaria was prevalent. This means that antibodies against PvMSP1c may persist for more than 30 years, the malaria-free duration. This long-term memory of humoral immunity supports the C-terminal region of merozoite surface protein 1 as an effective malaria vaccine, in addition to the neutralizing activity reported previously.Keywords
This publication has 25 references indexed in Scilit:
- A direct sandwich ELISA to detect antibodies against the C-terminal region of merozoite surface protein 1 could be a useful diagnostic method to identify Plasmodium vivax exposed personsZeitschrift Fur Parasitenkunde-Parasitology Research, 2002
- Plasmodium falciparum : in vitro growth inhibition by febrile temperaturesZeitschrift Fur Parasitenkunde-Parasitology Research, 2001
- Naturally Acquired Antibody Responses to the C-Terminal Region of Merozoite Surface Protein 1 ofPlasmodium vivaxin KoreaClinical and Diagnostic Laboratory Immunology, 2001
- Immunological alterations associated with Plasmodium vivax malaria in South KoreaPathogens and Global Health, 2001
- Immunoglobulin G3 Antibodies Specific for the 19-Kilodalton Carboxyl-Terminal Fragment ofPlasmodium yoeliiMerozoite Surface Protein 1 Transfer Protection to Mice Deficient in Fc-γRI ReceptorsInfection and Immunity, 2000
- Expression and immunogenicity of the C-terminus of a major blood-stage surface protein of Plasmodium vivax, Pv20019, secreted from Saccharomyces cerevisiaeImmunology Letters, 1996
- Clinical Immunity to Plasmodium falciparum Malaria Is Associated with Serum Antibodies to the 19-kDa C-Terminal Fragment of the Merozoite Surface Antigen, PfMSP-lThe Journal of Infectious Diseases, 1996
- Antibodies inhibit the protease-mediated processing of a malaria merozoite surface protein.The Journal of Experimental Medicine, 1994
- Why do some African children develop severe malaria?Parasitology Today, 1991
- A single fragment of a malaria merozoite surface protein remains on the parasite during red cell invasion and is the target of invasion-inhibiting antibodies.The Journal of Experimental Medicine, 1990