Characterization of an Interferon-Resistant Mutant of the Human Breast Cancer Cell Line BT-20
- 1 April 1987
- journal article
- research article
- Published by Mary Ann Liebert Inc in Journal of Interferon Research
- Vol. 7 (2) , 195-202
- https://doi.org/10.1089/jir.1987.7.195
Abstract
The human breast cancer cells BT-20 were treated for 18 months in the continuous presence of interferon-ύ (HuIFN-ύ; 500 U/ml). These cells have become completely resistant to HuIFN-ύ and interestingly also to IFN-α2. However, the expression of HLA-DR and the regulation of cell adhesion to tissue culture plastic remained partially under the domain of HuIFN-ύ. A reduced number of IFN-ύ binding sites in comparison to the wildtype cells were observed on the IFN-resistant BT-20 cells.This publication has 23 references indexed in Scilit:
- Isolation of Daudi Cells with Reduced Sensitivity to Interferon. III. Interferon-induced Proteins in Relation to the Phenotype of Interferon ResistanceJournal of General Virology, 1985
- Effect of Human Recombinant Alpha-2-and Gamma-Interferon on the Growth of Human Cell Lines from Solid Tumors and Hematologic MalignanciesJournal of Interferon Research, 1985
- Biochemical analysis of mutants of a macrophage cell line resistant to the growth-inhibitory activity of interferon.The Journal of cell biology, 1984
- Isolation of Daudi Cells with Reduced Sensitivity to Interferon.: I. CharacterizationJournal of General Virology, 1983
- Isolation of Daudi Cells with Reduced Sensitivity to Interferon. II. On The Mechanisms of ResistanceJournal of General Virology, 1983
- Antitumor effects of interferon in mice injected with interferon‐sensitive and interferon‐resistant friend leukemia cells. I.International Journal of Cancer, 1982
- Effects of HuIFN-α2 and HuIFN-α (Namalwa) on Breast Cancer Cells Grown in Culture and as Xenografts in the Nude MouseJournal of Interferon Research, 1982
- Effects of Interferon on Sensitive and Resistant L1210 Cell Lines.Journal of Interferon Research, 1981
- High-affinity binding of 125I-labelled mouse interferon to a specific cell surface receptorNature, 1980
- Distinctive banded marker chromosomes of human tumor cell linesInternational Journal of Cancer, 1975