Mechanism of action of rapamycin: New insights into the regulation of G1-phase progression in eukaryotic cells
- 1 January 1995
- book chapter
- Published by Springer Nature
- Vol. 1, 53-71
- https://doi.org/10.1007/978-1-4615-1809-9_5
Abstract
The immunosuppressant drug, rapamycin (RAP), is a potent inhibitor of IL-2-dependent T-cell proliferation. The antiproliferative effect of RAP is mediated through the formation of an active complex with its cytosolic receptor protein, FKBP12. The molecular target of the FKBP12-RAP complex is a putative lipid kinase termed the mammalian Target Of Rapamycin (mTOR). This review will discuss recent findings suggesting that mTOR is a novel regulator of G1 to S-phase progression in eukaryotic cells.Keywords
This publication has 130 references indexed in Scilit:
- Activation of p70/p85 S6 kinase by a pathway independent of p21fi rasNature, 1994
- A Putative Sirolimus (Rapamycin) Effector ProteinBiochemical and Biophysical Research Communications, 1994
- Molecular Cloning and Expression of a Novel Human Gene That Is Highly Homologous to Human FK506-Binding Protein 12kDa (hFJBP-12) and Characterization of Two Alternatively Spliced TranscriptsBiochemical and Biophysical Research Communications, 1994
- Signal transduction by lymphocyte antigen receptorsCell, 1994
- Target of rapamycin in yeast, TOR2, is an essential phosphatidylinositol kinase homolog required for G1 progressionCell, 1993
- Targets for Cell Cycle Arrest by the Immunosuppressant Rapamycin in YeastScience, 1991
- Two distinct signal transmission pathways in T lymphocytes are inhibited by complexes formed between an immunophilin and either FK506 or rapamycin.Proceedings of the National Academy of Sciences, 1990
- CyclosporineNew England Journal of Medicine, 1989
- A cytosolic binding protein for the immunosuppressant FK506 has peptidyl-prolyl isomerase activity but is distinct from cyclophilinNature, 1989
- A Randomized Clinical Trial of OKT3 Monoclonal Antibody for Acute Rejection of Cadaveric Renal TransplantsNew England Journal of Medicine, 1985