.beta.-Adrenergic blocking agents. 22. 1-Phenoxy-3-[[(substituted-amido)alkyl]amino]-2-propanols

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Abstract
The synthesis of a series of 1-phenoxy-3-[[(sustituted-amido)alkyl]amino]-2-propanols is described. Many of the compounds are more potent than propanolol as .beta. blockers, while having cardioselectivity comparable to that of practolol, when given i.v. to anesthetized cats. The structure-activity relationships shown by this series of compounds provide further evidence that the addition of substituents to the alkylamino moiety of a .beta. blocker can confer cardioselectivity and that amidic substituents are remarkably effective.