Subtle variations in living conditions influence behavioural response to d-amphetamine

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Abstract
The influence of prior living conditions on behaviours related to the reinforcing properties of d-amphetamine was determined. Rats were housed either in bright light (BL) conditions at the top of a standard rack or in dim light (DL) conditions on the third row of the same rack. Although BL rats showed a higher locomotor response in the novel environment, they were less sensitive than DL rats to the locomotor activating effects of d-amphetamine. The groups did not differ in responding for a secondary reinforcer in a conditioned reinforcement paradigm. However, only in DL rats as the response for the secondary reinforcer enhanced by d-amphetamine. These findings indicate that subtle differences in housing conditions can influence behavioural responses to psychoactive drugs.

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