Nitazoxanide Treatment for Giardiasis and Cryptosporidiosis in Children

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Abstract
OBJECTIVE To review the pharmacology, pharmacokinetics, adverse effects, drug interactions, dosing recommendations, and clinical efficacy of nitazoxanide, a new antiprotozoal/anthelmintic/antibacterial agent. DATA SOURCES A MEDLINE search (1966-February 2004) of both human and animal research data published in the English language was conducted. STUDY SELECTION AND DATA EXTRACTION All primary and review articles pertaining to the MEDLINE search were reviewed for inclusion. Emphasis was placed on randomized, double-blind, placebo-controlled trials. DATA SYNTHESIS Nitazoxanide is approved for the treatment of giardiasis and cryptosporidiosis (first drug approved for the latter indication) in immune-competent children CONCLUSIONS Nitazoxanide should be available for patients unable to tolerate or adhere to first-line therapy employed for these intestinal protozoa. THIS ARTICLE IS APPROVED FOR CONTINUING EDUCATION CREDIT ACPE UNIVERSAL PROGRAM NUMBER: 407-000-04-014-H01

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