Continuous on-line measurement of absolute left ventricular volume by transcardiac conductance: Angiographic validation in sheep

Publisher Website
Google Scholar
Abstract
Validation of the transcardiac conductance method for continuous, on-line measurement of absolute left ventricular volume by comparison with biplane angiography. Controlled, prospective animal study. Catheterization laboratory of the Leiden University Medical Center. Six anesthetized sheep. Subjects were studied at baseline, during infusion of dobutamine, and during volume loading and beta blockade. In a pilot experiment, a coronary artery was occluded by a balloon, and the behavior of the transcardiac conductance signals during ischemia was tested. Calibration factors α and Vp were determined by thermodilution and hypertonic saline dilution, respectively. Calibrated transcardiac conductance volume was compared with angiographic volume in four different hemodynamic conditions, and transcardiac conductance measurements were registered during a period of ischemia. Results showed a good linear correlation between transcardiac conductance and angiographic volume (r = .77, p p Transcardiac conductance is a method to register an on-line, continuous, left ventricular volume signal, which correlates well with angiography. However, calibration factors need to be determined in individual subjects. The method appears promising to monitor absolute volume in the intensive care unit.

This publication has 16 references indexed in Scilit: