Disseminated zoster, hyponatraemia, severe abdominal pain and leukaemia relapse: recognition of a new clinical quartet after bone marrow transplantation
- 1 October 2003
- journal article
- case report
- Published by Oxford University Press (OUP) in British Journal of Dermatology
- Vol. 149 (4) , 862-865
- https://doi.org/10.1046/j.1365-2133.2003.05656.x
Abstract
Reactivation of varicella‐zoster virus (VZV) is one of the commonest complications after stem cell transplantation, and often presents with atypical manifestations. We describe two unusual cases of occult disseminated zoster in allogeneic stem cell transplant recipients, presenting as severe abdominal pain and syndrome of inappropriate antidiuretic hormone secretion/hyponatraemia, and accompanied by leukaemia relapse. There was complete clinical recovery with high‐dose aciclovir and intravenous immunoglobulin. Prompt treatment of leukaemia relapse also resulted in complete remission. A possible immunological link between concurrent breakdown of immune control of VZV and leukaemia is discussed.Keywords
This publication has 10 references indexed in Scilit:
- Inappropriate antidiuretic hormone secretion, abdominal pain and disseminated varicella-zoster virus infection: an unusual and fatal triad in a patient 13 months post Rituximab and autologous stem cell transplantationClinical and Laboratory Haematology, 2001
- Fulminant molluscum contagiosum infection and concomitant leukaemia cutis after bone marrow transplantation for chronic myeloid leukaemiaBritish Journal of Dermatology, 2000
- Inappropriate antidiuretic hormone secretion, abdominal pain and disseminated varicella-zoster virus infection: an unusual triad in a patient 6 months post mini-allogeneic peripheral stem cell transplant for chronic myeloid leukemiaBone Marrow Transplantation, 2000
- Acute abdomen without cutaneous signs of varicella zoster virus infection as a late complication of allogeneic bone marrow transplantation: importance of empiric therapy with acyclovirBone Marrow Transplantation, 2000
- Varicella zoster virus infections following allogeneic bone marrow transplantation: Frequency, risk factors, and clinical outcomeTransplantation and Cellular Therapy, 2000
- Visceral Varicella-Zoster after bone marrow transplantation: report of a case series and review of the literatureAmerican Journal of Gastroenterology, 1998
- Varicella‐Zoster Virus (VZV) DNA in Cerebrospinal Fluid of Patients Infected with Human Immunodeficiency Virus: VZV Disease of the Central Nervous System or Subclinical Reactivation of VZV Infection?Clinical Infectious Diseases, 1997
- Varicella Pneumonia in a Healthy Adult Presenting with Severe Respiratory Failure.Internal Medicine, 1996
- Herpes Zoster Infection of the Chest Wall and the Syndrome of Inappropriate Antidiuretic Hormone SecretionSouthern Medical Journal, 1990
- Disseminated varicella-zoster virus infection with the syndrome of inappropriate antidiuretic hormoneArchives of internal medicine (1960), 1983