CD4+ CD25+ Treg: divide and rule?
- 21 January 2004
- journal article
- review article
- Published by Wiley in Immunology
- Vol. 111 (2) , 129-137
- https://doi.org/10.1111/j.0019-2805.2003.01788.x
Abstract
Summary: Research on CD4+ CD25+ regulatory T cells (Treg) has gathered momentum over the last five years but many aspects of their fundamental biology remain elusive. Treg have been considered to be ‘naturally anergic’ based on their failure to proliferate in response to T‐cell receptor ligation in vitro. Several recent studies challenge this view and demonstrate a robust proliferative capacity for CD25+ cells. The significance of this finding for Treg homeostasis and function is considered below.Keywords
This publication has 85 references indexed in Scilit:
- Thymic selection of CD4+CD25+ regulatory T cells induced by an agonist self-peptideNature Immunology, 2001
- IL-10 Is Required for Regulatory T Cells to Mediate Tolerance to Alloantigens In VivoThe Journal of Immunology, 2001
- CD25+ CD4+ T Cells Regulate the Expansion of Peripheral CD4 T Cells Through the Production of IL-10The Journal of Immunology, 2001
- Induction of Interleukin 10–Producing, Nonproliferating Cd4+ T Cells with Regulatory Properties by Repetitive Stimulation with Allogeneic Immature Human Dendritic CellsThe Journal of Experimental Medicine, 2000
- CD25 Is a Marker for CD4+ Thymocytes That Prevent Autoimmune Diabetes in Rats, But Peripheral T Cells with This Function Are Found in Both CD25+ and CD25− SubpopulationsThe Journal of Immunology, 2000
- Naturally anergic and suppressive CD25+CD4+ T cells as a functionally and phenotypically distinct immunoregulatory T cell subpopulationInternational Immunology, 2000
- Cytotoxic T Lymphocyte–Associated Antigen 4 Plays an Essential Role in the Function of Cd25+Cd4+ Regulatory Cells That Control Intestinal InflammationThe Journal of Experimental Medicine, 2000
- Immunologic Self-Tolerance Maintained by Cd25+Cd4+Regulatory T Cells Constitutively Expressing Cytotoxic T Lymphocyte–Associated Antigen 4The Journal of Experimental Medicine, 2000
- CD4+CD25+ regulatory T cells down-regulate co-stimulatory molecules on antigen-presenting cellsEuropean Journal of Immunology, 2000
- Repertoire Requirements of CD4+ T Cells That Prevent Spontaneous Autoimmune EncephalomyelitisThe Journal of Immunology, 2000