Synthesis of cephalosporin-4-aldehydes
- 1 January 1977
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of Medicinal Chemistry
- Vol. 20 (1) , 173-175
- https://doi.org/10.1021/jm00211a041
Abstract
The first reported synthesis of cephalosporin-4-aldehyde derivatives was achieved via Moffatt oxidation of the corresponding 4-hydroxymethylcephalosporins. An aldehyde was converted into a number of polar derivatives, in particular the acrylic acid derivative, which is the 4-vinylogue of sodium cephalothin. None of the new cephalosporin derivatives possessed useful antibacterial activity.This publication has 1 reference indexed in Scilit:
- Chemistry of Cephalosporin Antibiotics. V.1 Amides and Esters of Cephalothin2Journal of Medicinal Chemistry, 1966