Effect of clonidine at steady state on blood pressure in spontaneously hypertensive rats: Interaction of various alpha‐adrenoceptor antagonists
- 1 January 1984
- journal article
- research article
- Published by Wiley in Acta Physiologica Scandinavica
- Vol. 120 (1) , 37-42
- https://doi.org/10.1111/j.1748-1716.1984.tb07370.x
Abstract
The influence of various α‐adrenoceptor antagonists (phentolamine, yohimbine, R 28935, prazosine, terazosine) on clonidine's blood pressure effects at different steady state plasma concentrations was investigated in awake spontaneous hypertensive rats. Clonidine's threshold (>10 mmHg,1‐and α2‐antagonists. The effect of clonidine on blood pressure thus seems a consequence of both the tissue distribution and the α‐adrenoceptor affinity. At low steady state plasma concentrations of clonidine a peripheral action could be a part of the antihypertensive mechanism.This publication has 22 references indexed in Scilit:
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